Carbon Dioxide Angiography in Diabetic Critical Limb Ischemia Patients

The use of digital subtraction angiography with iodinated contrast is a common invasive imaging technique for diagnostic and interventional vascular procedures.

However, this approach is associated with an increased risk of contrast-induced acute kidney injury (CI-AKI) among diabetic patients with baseline chronic kidney disease (CKD).

1,2 The reported incidence of CI-AKI is 5.1% in patients with baseline CKD who undergo peripheral interventions.3 Because of its lack of nephrotoxicity and potential for allergic reactions, carbon dioxide (CO2) has been used as a contrast medium for evaluating patients with renal dysfunction.

4-8 To decrease procedure-related  complications such as CI-AKI and allergic reactions, we have focused on the potential benefits of CO2 as a contrast agent during invasive diagnostic procedures in the lower limbs.

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